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Technology DescriptionAntiviral effects of antisense morpholino oligomers in murine coronavirus infection models.
CategoryTechnology
PRCScripps Research Institute
PubMed ID17344287
AuthorBurrer R, Neuman BW, Ting JP, Stein DA, Moulton HM, Iversen PL, Kuhn P, Buchmeier MJ
Publication DescriptionWe have used several strains of murine hepatitis virus (MHV) in cell culture and in vivo in mouse models to investigate the antiviral characteristics of peptide-conjugated antisense phosphorodiamidate morpholino oligomers (P-PMOs).
MethodologyTen P-PMOs directed against various target sites in the viral genome were tested in cell culture, and one of these (5TERM), which was complementary to the 5' terminus of the genomic RNA, was effective against six strains of MHV.
Contact National Institute of Allergy and Infectious Disease National Institutes of Health National Institutes of Health