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Technology Description	Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers.
Category	Technology
PRC	Scripps Research Institute
PubMed ID	16014928
Author	Neuman BW, Stein DA, Kroeker AD, Churchill MJ, Kim AM, Kuhn P, Dawson P, Moulton HM, Bestwick RK, Iversen PL, Buchmeier MJ
Publication Description	Peptide-conjugated antisense morpholino oligomers (P-PMO) were designed to bind by base pairing to specific sequences in the SARS-CoV (Tor2 strain) genome. The P-PMO were tested for their capacity to inhibit production of infectious virus as well as to probe the function of conserved viral RNA motifs and secondary structures.
Methodology	The antisense-mediated suppression of viral replication can be achieved by binding to conserved RNA elements implicated in viral RNA synthesis and translation.