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Technology DescriptionCharacterization of strategies for obtaining confident identifications in bottom-up proteomics measurements using hybrid FTMS instruments
CategoryTechnology
PRCPacific Northwest National Laboratory
PubMed ID18855412
AuthorTolmachev AV, Monroe ME, Purvine SO, Moore RJ, Jaitly N, Adkins JN, Anderson GA, Smith RD.
Publication DescriptionPNNL explored three alternative strategies for high throughput proteomics measurements using hybrid FTMS instruments.
MethodologyPNNL investigated three approaches for shotgun protein identification by combining MS and MS/MS information obtained in MudPIT experiments using LTQ-Orbitrap and showed improved protein identification sensitivity for low-abundance proteins when the results from MS and MS/MS analyses are combined.
Contact National Institute of Allergy and Infectious Disease National Institutes of Health National Institutes of Health