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Technology Detail
Technology DescriptionThe visual Platform for Proteomics Peptide and Protein data exploration (PQuad) is a multi-resolution environment that visually integrates genomic and proteomic data for prokaryotic systems, overlays categorical annotation and compares differential expression experiments.
CategorySoftware
PRCPacific Northwest National Laboratory
PubMed ID17483503
AuthorBobbie Jo M. Webb Robertson, Elena S. Peterson, Mudita Singha, Kyle R. Klicker, Chris-topher S. Oehmen, Joshua N. Adkins and Susan L. Havre
Publication DescriptionPQuad offers the capability to map colors based on category definitions into the Genome and ORF Views. In the ORF View, for example, this would allow users to quickly identify if genes that are up-regulated in a microarray experiment are also expressed in the corresponding proteomic experiment. One of the most useful applications for categorical data integration is comparative proteomics to evaluate peptide/protein identification information from two or more different experimental conditions. Color is used to differentiate both peptide and protein expression across two experimental conditions.
MethodologyPQuad is a new visual analysis tool for proteomics that facilitates analysis of complex mixtures of proteins in multiple conditions for prokaryotic systems. Additionally, PQuad offers basic data integra-tion capabilities by mapping categorical information onto the pep-tide and protein expression data. Development as an object-oriented application allows new visualizations to be added rela-tively easily.
Resourcehttp://ncrr.pnl.gov/software/PQuad.stm

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