PNNL constructed in-frame non-polar deletions of 84 regulators thought to play a role
in Salmonella typhimurium virulence and tested them for virulence. (Pathogen data)
Experiment/Assay Design
Proteomics profiling was carried out for each of the 15 most attenuated mutants
under four different conditions to identify proteins coordinately regulated by
Salmonella regulatory proteins.